DNA-Peptide Amphiphile Nanofibers Enhance Aptamer Function
نویسندگان
چکیده
منابع مشابه
Self-assembly and mineralization of peptide-amphiphile nanofibers.
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite materia...
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introduction: in the present study, we hypothesized that a novel approach to promote vascularization would be to create injectable three dimensional (3-d) scaffolds within growth factor that enhance the sustained release of growth factor and induce the angiogenesis. material and methods: we demonstrate that a 3-d scaffold can be formed by mixing of peptide-amphiphile (pa) aqueous solution with ...
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1. International Center for Young Scientists, National Institute for Materials Science, Nano and Biomaterials Research Building, Tsukuba, Ibaraki, JAPAN 2. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University Hospital, Kyoto, JAPAN 3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA 4. Medicin...
متن کاملMineralization of peptide amphiphile nanofibers and its effect on the differentiation of human mesenchymal stem cells.
One of the important targets in regenerative medicine is to design resorbable materials that can promote formation of new bone in large skeletal defects. One approach to this challenge is to use a bioactive and biodegradable organic matrix that can promote cellular adhesion and direct differentiation. We have here studied matrices composed of peptide amphiphiles (PAs) that self-assemble into na...
متن کاملPeptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials.
Twelve derivatives of peptide-amphiphile molecules, designed to self-assemble into nanofibers, are described. The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity. The results demonstrate the chemically versatile nature of this supramolecular sys...
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ژورنال
عنوان ژورنال: ACS Applied Bio Materials
سال: 2019
ISSN: 2576-6422,2576-6422
DOI: 10.1021/acsabm.9b00310